Sciatica Research Today is a free monthly online journal that collates and summarizes the latest research about Sciatica, including details on treatment, prevention, medication. | ||||||||
|
Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats.Ma F, Xie H, Dong ZQ, Wang YQ, Wu GC Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, Shanghai Medical College of Fudan University, P.O. Box 291, 138 Yi Xue Yuan Road, Shanghai 200032, China. The present study was designed to investigate changes of opioid receptor like 1 receptor (ORL(1), NOP) mRNA expression in some pain-related brain nuclei of neuropathic pain rats using in situ hybridization technique. Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of ORL(1), plays an important role in neuropathic pain through its receptor. There are ORL(1) mRNA expression in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) of rat mesencephalon. In the sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain model, a significant increase of ORL(1) mRNA expression was observed in these three regions on the 7th day after operation, and the changes lasted for 2 weeks. The result indicated that ORL(1) synthesis was increased in NRM, vlPAG and DRN of neuropathic pain rats, suggesting that ORL(1) was involved in nociceptive transmission of neuropathic pain. Published 2 May 2005 in Brain Res, 1043(1): 214-7.
© 2004-2008 Sciatica Research Today. All Rights Reserved. |
| ||||||
