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Dramatic etanercept-induced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene.

Serratrice J, de Roux-Serratrice C, Disdier P, Dodé C, Weiller PJ

Service de Médecine Interne, du Professeur Pierre Jean Weiller, CHU de La Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 05, France.

An adult patient experienced attacks of severe low back pain and sciatic neuralgia for several years, sometimes associated with myalgias, skin lesions, and high fever. Specific inflammatory laboratory tests were the major abnormalities. P46L mutation in the gene on chromosome 12p13 that encodes tumor necrosis factor receptor superfamily 1A (TNFRSF1A) was found. Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever.

Published 30 July 2007 in Clin Rheumatol, 26(9): 1535-6.
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